Description
Melanotan II (MT-II) is a synthetic 7-amino acid peptide classified as a melanocortin receptor agonist. Developed as an analog of the naturally occurring hormone α-melanocyte-stimulating hormone (α-MSH), MT-II was originally designed to investigate the body’s melanogenesis pathways and their effects on skin pigmentation. By activating melanocortin receptors, particularly MC1R and MC4R, Melanotan II has become a significant research compound in studies involving skin pigmentation, UV protection, and sexual function.
Research has demonstrated that MT-II stimulates melanin production within melanocytes, resulting in increased skin pigmentation independent of ultraviolet light exposure. This has generated interest in its potential applications in studies focused on reducing UV-related skin damage and improving photoprotection. Additionally, activation of central melanocortin receptors has been associated with effects on appetite regulation and sexual behavior, leading to significant research into its role in libido enhancement, sexual arousal, and energy balance. These findings have positioned Melanotan II as a versatile peptide for ongoing investigations in dermatology, endocrinology, and neurobiology.
CAS Number: 121062-08-6
Chemical Formula: C50H69N15O9
Molecular Weight: 1024.18 g/mol
Sequence: Ac-Nle-c[Asp-His-D-Phe-Arg-Trp-Lys]-NH2
Melanotan II exerts its biological effects through activation of the melanocortin receptor family, particularly MC1R, which regulates melanin synthesis, and MC4R, which plays a role in appetite and sexual function. Research models have demonstrated increased eumelanin production following administration, which may contribute to improved resistance to ultraviolet radiation and oxidative stress associated with UV exposure.
Beyond pigmentation research, MT-II has been extensively studied for its effects on central nervous system pathways involved in sexual behavior and arousal. Clinical investigations have demonstrated measurable effects on erectile response and libido, leading to the development of related melanocortin compounds for sexual health research. Additional studies continue to explore potential applications in appetite control, energy expenditure, and body composition regulation.
Current research also investigates the role of melanocortin signaling in inflammation, immune modulation, and neuroprotection, expanding the potential applications of MT-II beyond its original dermatologic focus. As a well-characterized melanocortin agonist with decades of scientific interest, Melanotan II remains an important research peptide for advancing our understanding of pigmentation biology, neuroendocrine regulation, and metabolic signaling pathways.
Axiom Peptide proudly supplies high-purity, research-grade Melanotan II (MT-II) manufactured to rigorous quality standards for advanced scientific and laboratory research applications.
