Description
KPV (Lysine-Proline-Valine) is a synthetic 3-amino acid peptide derived from the C-terminal sequence of alpha-melanocyte stimulating hormone (α-MSH). Classified as an anti-inflammatory and immunomodulatory peptide, KPV has gained significant attention in research due to its ability to regulate inflammatory pathways without the broader hormonal effects associated with the full α-MSH molecule. Researchers have extensively studied KPV for its potential applications in gastrointestinal health, immune regulation, and inflammatory skin conditions.
Studies have demonstrated that KPV can inhibit the production of pro-inflammatory cytokines including TNF-α, IL-1β, and IL-6 while supporting intestinal barrier integrity and immune homeostasis. This has generated considerable interest in its potential role in research involving inflammatory bowel disease (IBD), ulcerative colitis, Crohn’s disease, and various dermatological inflammatory conditions. Significant findings suggest KPV may reduce oxidative stress, support tissue recovery, and improve epithelial healing while exhibiting antimicrobial activity against certain pathogenic organisms.
CAS Number: 67727-97-3
Chemical Formula: C18H32N4O5
Molecular Weight: 384.47 g/mol
Sequence: Lys-Pro-Val
KPV exerts its biological activity primarily through modulation of inflammatory signaling pathways, including inhibition of nuclear factor-kappa B (NF-κB) activation and reduction of pro-inflammatory cytokine production. Unlike many anti-inflammatory compounds, KPV appears to regulate immune responses without causing generalized immune suppression, making it particularly attractive for studies involving chronic inflammatory conditions.
In gastrointestinal research, KPV has demonstrated the ability to preserve intestinal epithelial integrity, reduce mucosal inflammation, and support restoration of normal barrier function. Animal studies investigating inflammatory bowel disorders have shown reductions in tissue damage, inflammatory cell infiltration, and cytokine production following KPV administration. These findings have led to growing interest in peptide-based approaches to gut health and mucosal healing.
Dermatologic research has also highlighted KPV’s potential role in reducing inflammation associated with conditions involving excessive immune activation and oxidative stress. Its antimicrobial properties and favorable safety profile have further expanded investigations into wound healing and tissue recovery applications.
Current research continues to explore KPV’s role in immune regulation, gastrointestinal health, skin inflammation, and systemic inflammatory disorders. As one of the smallest bioactive peptides under investigation, KPV offers a unique opportunity to study highly targeted anti-inflammatory mechanisms while minimizing off-target biological effects.
Axiom Peptide proudly supplies high-purity, research-grade KPV manufactured to rigorous quality standards for advanced scientific and laboratory research applications.
